Thomas Max-Planck Institute for Neurological Research

TITLE: Forecast Trypanozidempfindlichkeiten non – small cell lung cancer due to genetic lesions onAUTHOR CONTACT : Roman K. Thomas Max-Planck – Institute for Neurological Research, GermanyKwok-Kin Wong, Dana-Farber Cancer Institute, Harvard Medical School, Massachusetts,Matthew Meyerson, Dana-Farber Cancer Institute, Harvard Medical School, Massachusetts,View PDF of this article at:ONCOLOGY: No response to TGF-beta is bad for those with breast cancerIn the human breast cancer, has poor prognosis with loss of cancer cell reaction brought on in connection signaling from the TGF-beta molecule triggered . To understand the allocation clear, Harold Moses and colleagues, Vanderbilt University, Nashville, mouse breast cancer cell lines are used to gene expression signatures of breast cancer cells do not. In response to TGF-beta and the cells that produce the molecule These gene expression signatures were compared with four existing human breast cancer gene expression data sets contain profiles and associated clinical data for 1,319 patients. The gene signature representatives no response to TGF – beta with reduced relapse – free survival in all patients correlated. This association was particularly strong in patients with estrogen – receptor-positive cancer, especially those with the luminal sub-type of breast cancer. The authors therefore suggest syndrome. Assessment of TGF-beta responsiveness may prognosis for patients with prognosis for patients with estrogen receptor-positive breast cancer and show those patients who from from aggressive therapy.

The team led by Roman Thomas, Kwok-Kin Wong , and Matthew Meyerson conducted, established that the genomes of a large group of human NSCLC cell lines highly representative of those of primary NSCLC tumors. Meyerson, cell lines, they identify genomic and molecular indicators of response to clinically relevant agents. For example, were cell lines with an increased number of copies of the genes ABL2 and / or an increased number of copies of the Ephrin receptor kinase kinase family and SRC gene is sensitive to the treatment, with a clinically used SRC / ABL inhibitor , both in vitro and when it mice mice. The authors suggest that the cell line collection is featured here provide a tool to study the effect of potential new anticancer drugs in genomically defined cancers and thereby to define the patients with a drug will be most effective.

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