Atsunori Kashiwagi from Shiga University of Medical Research offered data from a 12-week dose finding research in 361 Japanese patients with Type 2 diabetes mellitus. This study showed dosage related and statistically significant decreases in HbA1c in comparison to baseline and against placebo of up to 1.3 percent reaching a optimum at the 50 mg dosage. ASP1941 reduced bodyweight dose-dependently and statistically significant by up to 2 kg in the 100 mg group after 12 weeks. All dosages had been well tolerated.This group includes omeprazole , lansoprazole , rabeprazole , and pantoprazole , dexlansoprazole , and esomeprazole . Proton pump inhibitors are even more powerful than H2 blockers. They function by stopping the pump that secretes acid into the stomach. They are becoming used increasingly in triple and dual regimens for infection. Protective agents: These drugs do not affect the quantity of acid in the belly; instead, they shield the mucous lining of the belly from acid. One type is quite heavy and sticks to the ulcer, forming a physical barrier between the ulcer and the acid.