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Cachexia reduces function and changes muscle framework of center in mice with colon cancer The wasting disease associated with some cancers that’s typically seen affecting skeletal muscle groups can also cause significant harm to the heart, new research in mice suggests. Before now, cachexia, characterized by muscle mass wasting and dramatic pounds loss, was thought to spare the center. But an Ohio State University study showed that the condition reduces heart function and adjustments the heart muscle structure in mice with colon cancer.