In addition they used mice where the BRCA1 gene was partially deleted, but only in breasts tissue. The animals had been treated with estrogen, or progesterone, or both, and response of the mammary gland was weighed against that of regular mice. In this real way, the researchers figured BRCA1 interacts actually with the progesterone receptor, and stops it from activating various other genes. It can this in the lack of the progesterone hormone also, and, thus, functions as a strong check up on errant growth.. BRCA1 gene inhibits progesterone and estrogen It has been known that the breasts tumor susceptibility gene BRCA1 regulates usage of estrogen in breasts and other cells, however now researchers in Georgetown University INFIRMARY have discovered that in addition, it controls activity of another sex steroid hormone, progesterone.The extensive research by Dr. Karen Canfell found that between 2001 and 2003, there was a 40 per cent drop in HRT prescribing in Australia, and at exactly the same time there was seven percent drop in breast malignancy rates in women over 50 years of age. Dr. Canfell says the analysis supports other international research and shows that women can reduce their risk of breast cancer just by using HRT for the very least period. The Therapeutic Goods Administration recommends hormone substitute therapy be used in the short-term for the administration of the symptoms of menopause. Many professionals believe current recommendations regarding HRT even now apply and say the scholarly study simply confirms what was already known.