Antibiotics could treat cystic fibrosis.

Antibiotics could treat cystic fibrosis, other genetic diseases By modifying the properties of the normal antibiotic gentamicin, researchers at the Technion-Israel Institute of Technology have developed what could become an effective treatment for most human genetic illnesses, including cystic fibrosis , Duchenne muscular dystrophy, Usher Syndrome and numerous cancers. The findings were published on-line March 23rd by the Journal of Medicinal Chemistry . Gentamicin belongs to a class of antibiotics known as aminoglycosides, which are used to treat an array of bacterial infections. Research show that gentamicin can counteract genetic illnesses, including those mentioned above that occur when mutations trigger disruptions of the development procedures of proteins.

What the Scripps Analysis scientists found is usually that CR6261 latches on to the ‘stalk’ of the mushroom-like hemagglutinin particle, near where in fact the protein juts right out of the viral layer, and that binding area, called an epitope, may be the same in both H1 and H5 infections. The scientists then analyzed the genome greater than 5,000 different influenza viruses and discovered the epitope’s sequence is nearly identical in all of these, suggesting that this section of the virus is much more highly conserved than the virus’s continuously mutating cap. This insight in to the way the CR6261 antibody binds to the virus’s structure makes sense, the researchers say. It helps explains as to why the antibody may not be as powerful since it must be to attack influenza.