Access the full text of the study and editorial here.vsbit Biosciences Initiates First Phase 2 study in acute myeloid leukemia with AC220The study on data from a first-in-human Phase 1 clinical trial with AC220 presented this month based on the ASH meeting in New Orleans. The preliminary results from this trial in heavily pretreated patients with AML with predominantly relapsed or refractory AML showed that AC220 was generally well up and once daily continuous dosing of 200 mg, and no treatment mortality in the study generic pills here . In the study. Responses were seen in both FLT3 ITD – positive and FLT3 ITD – negative AML patients with a response rate of 56 % and 20 % respectively. Responders in both FLT3 ITD – positive and FLT3 ITD – negative groups had at least a doubling in median overall survival compared to non-responders , skin irritation, and peripheral edema. All of these drug-related adverse events occurred in less than 15 percent of the study population, most of which less than 10 percent of patients, and were marked primarily mild to moderate. In addition, some patients did QTcF interval prolongation, which The maximum tolerated dose reversible. The maximum tolerated dose was determined to be 200 mg continuous once-daily dosing.
Ambit Biosciences is a privately-held biopharmaceutical company engaged in the discovery and development of small molecule kinase inhibitors for the treatment of cancer, inflammatory diseases and other indications. Ambit employs novel and proprietary kinase profiling technology, KINOMEscan in order. Compounds against 442 human kinases.
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